Lucie Bruijn, Ph.D. MBA joined The ALS Association in January 2001 as Science Director and Vice President and is currently Chief Scientist for the organization. Prior to that Dr. Bruijn led a team of researchers in drug discovery programs for Parkinson and Alzheimer disease at Bristol Myers Squibb. She has served as a member of the National Institute of Neurological Disorders and Stroke (NINDS) advisory council. She is the former chair and current member of the integration panel of the Department of Defense (DOD) for the ALS Research Program supporting translational research for ALS and has served on the Data Safety and Monitoring Board for the Neuralstem trial, the first US stem cell trial for ALS. Dr. Lucie Bruijn continues to publish in peer-reviewed journals and attends scientific meetings throughout the year to ensure that the research portfolio maximizes opportunities in the field. In her role on the Scientific Advisory Board of Prize4Life. Dr. Lucie Bruijn has been engaged in developing one of the first Prize concepts for ALS bringing new players into the field. Most recently she has developed an Assistive Technology Prize for communications and a PET Tracer Challenge for TDP43, an abnormally accumulated protein present in ALS and other neurological disorders. These incentives have spurred significant interest from diverse expertise including imaging, biotechnology and bioengineering.
Lucie Bruijn(Research Area)
Dr. Lucie Bruijn leads a global research effort at the ALS Association. She has expanded on the existing TREAT ALS portfolio to include large international collaborative initiatives in drug development and precision medicine.
Roxana Carare is a medically qualified clinical neuroanatomist who graduated in general medicine in Bucharest Romania in 1996 and completed her PhD in experimental neuropathology in the Faculty of Medicine, University of Southampton, UK. She has a rich educational portfolio and leads research into the lymphatic drainage pathways of the brain. She has published more than 50 papers in peer- reviewed journals, 4 book chapters and has been serving as a board member on international organisations and an editorial board member of repute for several journals.
Roxana O Carare(Research Area)
The international recognition and unique contributions from the research that Roxana leads have derived from her interdisciplinary research demonstrating (i) the unique pathways by which fluid and soluble waste substances are eliminated from the brain along thin proteins layers (basement membranes) within the walls of cerebral capillaries and arteries; (ii) how this elimination pathway fails with advancing age, genotype, diet and following immunization against amyloid beta representing thus a significant factor in the pathogenesis of Alzheimer disease.
Jiying Zhou, MD, PhD, Professor of Neurology at the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Dr. Zhou is the Vice Chair of China Headache Society and the Chair of Chongqing Headache Society. She is on the editorial board of journals of the Journal of Chongqing Medical University, the Chongqing Medicine, and the Chinese Journal of Pain Medicine.
Jiying Zhou(Research Area)
Professor Jiying Zhou specializes in headache and dizziness, and has published 21 articles on Headache and other journals as corresponding author. The study about medication overused headache and hypertension was ranks third on MDLinx of the most influencing therapy for headache in 2013. She and her colleagues have developed the headache questionnaire scale, chronic daily headache clinic scale, and the online database named the Headache Medical History Management Database, the software copyright code, 2012SR09588 , which integrate with collecting, sorting, statistical analysis. These scales and database provide an important tool and a practical platform to headache clinical research. She won the first prize of Chongqing Medical Reward for her achievements in 2012. She has already chaired seven Headache and Facial Pain Chongqing Annual Conferences which now became a landmark in the field of headache in China.
Dr. Pant received his M.A. and Ph.D. degrees in Physics from Agra University, Agra, India. His postdoctoral studies were conducted on the mechanisms of electron and ion transport in model membrane systems at the Department of Biophysics at Michigan State University. He joined the Laboratory of Neurobiology in the NIMH as a senior staff fellow in 1974 with Dr. Ichiji Tasaki where he studied the function of the axonal cytoskeleton in the squid giant axon. In 1979 he moved to the NIAAA extending his studies on the neuronal cytoskeleton and the effects of alcohol on its regulation. Dr. Pant moved to the NINDS, Laboratory of Neurochemistry in 1987 where he is presently chief of the section on Cytoskeleton Regulation. His laboratory is studying the mechanisms of topographic regulation of neuronal cytoskeleton proteins by post-translational modification, including the role of kinase cascades in normal brain and during neurodegeneration.
Harish C. Pant(Research Area)
The major focus of the laboratory has been to study the mechanisms of topographic regulation of neuronal cytoskeletal proteins regulation by phosphorylation and neurodegeneration.
Giulio Maria Pasinetti is The Saunders Family Chair and Professor of Neurology at the Icahn School of Medicine at Mount Sinai. He is the Program Director of the NIH funded P50 Botanical Center on Molecular Integrative Neuroresilience. The primary goal of the Center grant is to understand the molecular mechanisms and pathophysiology that may be at the basis of stress-induced mood disorders, which are major risk factors for age-related neurodegeneration (such as in Alzheimer disease).
Giulio Pasinetti(Research Area)
Dr. Pasinetti Center is currently developing new studies to further the development and characterization of certain natural drugs against stressful events.
Jacqueline London (Emeritus Professor at University Paris-Diderot) has completed her PhD in the Pasteur Institute under the direction of Professor Jacques Monod (Nobel Price) and Professor Michel Goldberg in the field of protein folding and bacteriology (3 papers). She moved to immunology in Necker hospital under the direction of professor Jean Francois Bach and then was a visiting scientist at NIH (9 papers). After coming back to Paris she settled a laboratory in molecular biology at the Blood Center and cloned glycophorins A and B (13 papers). She then moved again to Necker Hospital where she joined the group working on Trisomy 21 and settled a laboratory to obtain transgenic mice for the SOD1 gene and cloned the murine CBS.
Jacqueline London(Research Area)
She had published some 35 papers on different aspects of trisomy 21 using transgenic mice for some chromosome 21 genes: APP CBS, DYRK1A and SOD1.