Neurology and Neurological Disorders

Biography

Hamada I Zehry is a consultant neurologist and have special interest in child neurology and abnormal movement. He had accepted poster presentation in child neurology section in last world congress of neurology Kyoto. Japan. He is PhD degree candidate since 2012 (in last part of PhD). He is working on the thesis entitled as, Basal Ganglionic Lesions In Egyptian Children: Radiological Findings In Correlation With Etiology And Clinical Manifestations.

 

Abstract

Background: In childhood, the metabolic activity of the basal ganglia is greater and they are particularly prone to injury. Damage to the basal ganglia cells may cause problems controlling speech, movement, consciousness, muscle tone, posture and cognition.

Aim of the study: To determine the etiology of basal ganglionic disorders in a sample of Egyptian children.

Methods: A cross sectional observational study was utilized on 34 patients attended at the Pediatric Neuro Outpatient Unit of Neurology department at Al-Azhar University Hospitals during a period of one year from the beginning of November 2014 to the end of November 2015. A specialized pediatric neurological sheet, cognitive assessment in children using Stanford-Binet Intelligence Scale and Laboratory investigations were performed. The included patients were classified according to MRI into two groups; ganglionic group that included patients with isolated basal ganglionic lesions (n=23) and para-ganglionic group that included patients with combined ganglionic as well as para-ganglionic lesions (n=11).

Results: The frequency of male patients was slightly higher than the female patients in both groups without significant difference (13(56.5%) versus 6(43.5%) and 10(54.5%) versus 5 (45.5%), in ganglionic and para-ganglionic groups, respectively). Acute ischemic stroke was the most frequent cause, which was found in 12(35.3%) cases, followed by 10(29.4%) had metabolic and infectious causes, and lastly 2(5.9%) had toxic causes. The incidence of toxic causes (CO poisoning) was significantly higher among ganglionic group compared to para-ganglionic group (2(8.7%) versus 0(0.0%), respectively). According to brain MRI imaging, bilateral basal ganglion affection was the most frequent lesions among ganglionic group 16 (69.7%) while temporal affection (temporal were 2(18.2%), tempro-parietal were 2(18.2%) and tempro-occipital was 1(9.1%) ) was the most frequent lesions among para-ganglionic group5(45.5%).

Conclusion: Acute ischemic stroke was the most frequent cause of basal ganglionic lesion in a sample of Egyptian children.